Description

10-Hydroxycamptothecin is a potent, naturally derived alkaloid and a key pharmaceutical intermediate. This compound matters for its critical role as a precursor in the synthesis of advanced anti-cancer agents, particularly topoisomerase I inhibitors. Pharmaceutical manufacturers and advanced research institutions need it for developing novel chemotherapeutic drugs and conducting pivotal preclinical studies on tumor biology.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of potent camptothecin-derived anti-cancer drugs like Irinotecan and Topotecan.
• Oncology Research: Serves as a reference standard and active compound in preclinical studies investigating topoisomerase I inhibition and apoptosis mechanisms.
• Active Pharmaceutical Ingredient (API) Development: Utilized in the R&D and production of novel chemotherapeutic formulations targeting solid tumors.
• Biochemical Research: Employed in studies of cell cycle dynamics, DNA damage response, and the development of drug resistance in cancer cell lines.
• Standards and Controls: Used in analytical laboratories for method development, validation, and quality control testing of related pharmaceutical products.

Basic Information

Product Name	10-Hydroxycamptothecin
CAS No.	64439-81-2
Molecular Formula	C20H16N2O5
Molecular Weight	364.35 g/mol
Synonyms	10-HCPT; 10-Hydroxy-20(S)-camptothecin; (S)-10-Hydroxycamptothecin; NSC 107124; CPT-10; Topotecan related compound A; 10-Hydroxy-(20S)-camptothecin; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-hydroxy-,(4S)-
EINECS	Contact for details

Quality Control

Our 10-Hydroxycamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or refrigerated (2-8°C) as specified. The container must be kept in a dry, well-ventilated area away from oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.