Description

(+/-) Cgp 12177A CAS NO 64208-32-8 is a high-purity chemical compound primarily utilized as a potent and selective β-adrenergic receptor antagonist in advanced research and development. Its significance lies in its role as a critical pharmacological tool for studying cardiovascular and neurological pathways, enabling precise modulation of adrenergic signaling. This product is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel therapeutics for conditions like hypertension, anxiety, and heart failure.

Application

• As a reference standard in analytical method development and validation for pharmaceutical quality control.
• For in vitro pharmacological studies investigating β-adrenergic receptor binding affinity and selectivity profiles.
• In preclinical research to model cardiovascular diseases and evaluate potential therapeutic interventions.
• Utilized as a key intermediate or biochemical tool in the synthesis and study of related adrenergic compounds.
• For mechanistic studies in neuropharmacology to understand autonomic nervous system regulation.
• In academic and institutional research exploring fundamental cellular signaling pathways mediated by β-receptors.

Basic Information

Product Name	(+/-) Cgp 12177A
CAS No.	64208-32-8
Molecular Formula	C16H21N3O3
Molecular Weight	303.36 g/mol
Synonyms	CGP 12177A; CGP-12177A; (±)-CGP 12177A; 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile; ICI 12177; CGP12177A Hydrochloride (salt form); 4-(3-(tert-Butylamino)-2-hydroxypropoxy)indole-2-carbonitrile
EINECS	Contact for details

Quality Control

Our (+/-) Cgp 12177A is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.