Description

4-(n-Nitrosomethylamino)-1-(3-Pyridyl)-1-Butanone is a specialized nitrosamine compound of significant interest in chemical research and development. Its primary value lies in its role as a key intermediate or reference standard for analytical and toxicological studies. This product is essential for researchers and quality control laboratories in the pharmaceutical, tobacco, and environmental monitoring sectors who require high-purity, well-characterized compounds for method development and safety assessment.

Application

• Analytical Reference Standard: Used as a certified standard for the quantification of nitrosamines in complex matrices via HPLC, GC-MS, or LC-MS/MS.
• Toxicology Research: Serves as a critical compound in studies investigating the metabolism, carcinogenicity, and biological impact of tobacco-specific nitrosamines (TSNAs).
• Pharmaceutical Impurity Profiling: Employed in method development and validation for detecting and controlling nitrosamine impurities in active pharmaceutical ingredients (APIs) and drug products to meet regulatory requirements (e.g., ICH M7).
• Environmental Analysis: Applied in monitoring and research programs to assess the presence of nitrosamine contaminants in water, soil, and industrial emissions.
• Chemical Synthesis Intermediate: Acts as a building block in the research-scale synthesis of more complex molecules for biological screening.
• Quality Control & Assurance: Utilized by testing laboratories to calibrate equipment and verify analytical procedures for nitrosamine detection.

Basic Information

Product Name	4-(n-Nitrosomethylamino)-1-(3-Pyridyl)-1-Butanone
CAS No.	64091-91-4
Molecular Formula	C10H13N3O2
Molecular Weight	207.23 g/mol
Synonyms	NNK; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone; N-Nitrosonornicotine ketone; Tobacco-specific nitrosamine NNK; 4-(N-Nitroso-N-methylamino)-1-(3-pyridinyl)-1-butanone; 1-(3-Pyridyl)-1-butanone 4-(methylnitrosoamino)-; (3-Pyridyl)-1-butanone, 4-(methylnitrosamino)-
EINECS	Contact for details

Quality Control

Every batch of 4-(n-Nitrosomethylamino)-1-(3-Pyridyl)-1-Butanone is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced chromatographic methods (HPLC, GC). Our quality systems are designed to support research requiring traceable and reliable reference materials, with specifications that can meet the demands of regulatory analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. For long-term stability, storage at -20°C is recommended. The container should be kept in a dry, well-ventilated area designated for laboratory chemicals.

Specification

Item	Specification
Appearance	Yellow to orange solid or oil
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95% (Research Grade)
Purity (GC)	≥ 95% (Research Grade)
Water Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.