Description

13,14-Dehydroprostaglandin I2 Methyl Ester is a chemically modified prostaglandin analog, specifically a methyl ester derivative of a dehydroprostacyclin. This compound is a valuable synthetic intermediate and research chemical in the field of medicinal chemistry and pharmacology. It is primarily utilized by pharmaceutical R&D teams and academic researchers for investigating cardiovascular and inflammatory pathways, as well as for the synthesis of more complex bioactive molecules. The product is supplied to meet the stringent requirements of advanced laboratory and process development applications.

Application

• Pharmaceutical Research & Development: A key synthetic intermediate for the preparation of novel prostacyclin analogs and related therapeutic candidates.
• Biochemical Studies: Used as a reference standard or tool compound in studies of prostaglandin receptors (IP receptor) and related signal transduction mechanisms.
• Medicinal Chemistry: Serves as a core building block for structure-activity relationship (SAR) studies aimed at developing new agents for cardiovascular and pulmonary diseases.
• Academic Research: Employed in university and institutional labs for fundamental research on eicosanoid biology, platelet aggregation, and vasodilation.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for prostaglandin-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	13,14-Dehydroprostaglandin I2 Methyl Ester
CAS No.	64079-44-3
Molecular Formula	C22H32O5
Molecular Weight	376.49 g/mol
Synonyms	13,14-Didehydro-15-deoxy-16-hydroxy-16-methylprostaglandin I2 Methyl Ester; Methyl (5Z,13E)-(9S,11R,15R)-9,11,15-Trihydroxy-16-methyl-13,14-didehydroprosta-5,13-dien-1-oate; 13,14-Didehydro-15-deoxy-16-hydroxy-16-methyl-PGI2 Methyl Ester; Dehydroprostacyclin Methyl Ester Derivative; Prostaglandin I2 (PGI2) Analog Methyl Ester
EINECS	Contact for details

Quality Control

Our 13,14-Dehydroprostaglandin I2 Methyl Ester is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your research and development documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.