Description

16,16-Dimethyl Prostaglandin D2 is a synthetic analog of the naturally occurring prostaglandin D2, featuring enhanced metabolic stability due to its dimethyl substitution at the 16-position. This compound is a critical research-grade biochemical tool for investigating prostanoid receptor signaling pathways and their roles in physiological and pathological processes. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on inflammation, allergy, and oncology research.

Application

• Pharmacological Research: A key reference standard and active agent for studying DP1 and DP2 (CRTH2) receptor pharmacology and signal transduction.
• Inflammation & Allergy Studies: Used in vitro and in vivo to model and investigate mechanisms underlying allergic responses, asthma, and inflammatory diseases.
• Cell Biology & Biochemistry: Employed as a tool compound to explore the role of prostaglandins in cell proliferation, differentiation, and apoptosis.
• Drug Discovery & Development: Serves as a precursor or intermediate in the synthesis of novel therapeutic agents targeting prostanoid pathways.
• Academic Research: Essential for university and institutional labs conducting fundamental research in lipid mediators and their biological functions.
• Biomarker Development: Used in the development and validation of analytical methods (e.g., LC-MS/MS) for quantifying prostaglandin metabolites in biological samples.

Basic Information

Item	Details
Product Name	16,16-Dimethyl Prostaglandin D2
CAS No.	64072-59-9
Molecular Formula	C22H36O5
Molecular Weight	380.52 g/mol
Synonyms	16,16-Dimethyl-PGD2; 9α,15S-Dihydroxy-11-oxo-16,16-dimethylprosta-5Z,13E-dien-1-oic acid; 16,16-Dimethylprostaglandin D2; 16,16-Dimethyl PGD2; DM-PGD2; Prostaglandin D2, 16,16-dimethyl-; (5Z,13E)-(9S,11R,15S)-9,15-Dihydroxy-11-oxo-16,16-dimethylprosta-5,13-dien-1-oic acid
EINECS	Contact for details

Quality Control

Our 16,16-Dimethyl Prostaglandin D2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.