Description

(-)-7-Carboxycannabidiol is a major, pharmacologically active metabolite of cannabidiol (CBD), distinguished by its carboxylic acid functional group. This compound is of significant interest for its role in pharmacokinetic studies and as a critical reference standard in analytical and pharmaceutical development. It is essential for researchers and manufacturers in the pharmaceutical, analytical chemistry, and cannabinoid research sectors who require high-purity materials for method validation, metabolite profiling, and drug development programs.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification and identification of CBD metabolites in biological matrices.
• Metabolite Profiling & Pharmacokinetics: Critical for studying the absorption, distribution, metabolism, and excretion (ADME) of cannabidiol in preclinical and clinical research.
• Analytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, and GC-MS methods for cannabinoid analysis in compliance with regulatory guidelines.
• Bioanalytical Assay Calibration: Serves as a calibration standard in assays designed to measure CBD and its metabolites in plasma, serum, and urine.
• Drug Impurity Testing: Employed as an impurity marker or specification in the quality control of CBD-based active pharmaceutical ingredients (APIs) and finished drug products.
• Preclinical Research: Utilized in *in vitro* and *in vivo* studies to investigate the activity and safety profile of CBD metabolites.

Basic Information

Product Name	(-)-7-Carboxycannabidiol
CAS No.	63958-77-0
Molecular Formula	C21H30O4
Molecular Weight	346.46 g/mol
Synonyms	7-COOH-CBD; 7-Carboxy-Cannabidiol; CBD-7-Carboxylic Acid; 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol; (-)-7-Carboxycannabidiol; 7-Carboxy-cannabidiol; 7-Carboxy cannabidiol; 7-Carboxy-CBD
EINECS	Contact for details

Quality Control

Our (-)-7-Carboxycannabidiol is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques, to ensure it meets the stringent requirements for use as a reference standard. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.