Description

Prostaglandin H2 Methyl Ester is a chemically stabilized methyl ester derivative of the key prostaglandin endoperoxide intermediate, PGH2. This compound is of significant value as a critical synthetic precursor and reference standard in advanced prostaglandin and eicosanoid research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers engaged in the development of bioactive lipid mediators and related therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of more complex prostaglandin analogs and derivatives for drug discovery programs.
• Biochemical Research: Used as a stable substrate or reference compound in enzymatic studies involving cyclooxygenase (COX) and other enzymes in the arachidonic acid cascade.
• Reference Standard: Employed as a high-purity analytical standard for the identification and quantification of prostaglandin metabolites in biological samples via HPLC or LC-MS methods.
• Medicinal Chemistry: Provides a core structure for structure-activity relationship (SAR) studies aimed at developing novel anti-inflammatory or vasoactive agents.
• Cell Signaling Studies: Utilized in laboratory investigations to study the role of prostaglandin intermediates in cellular signaling pathways and receptor interactions.

Basic Information

Product Name	Prostaglandin H2 Methyl Ester
CAS No.	63942-75-6
Molecular Formula	C21H34O6
Molecular Weight	382.49 g/mol
Synonyms	PGH2 Methyl Ester; (5Z,13E)-(15S)-9α,11α-Epidioxy-15-hydroxyprosta-5,13-dien-1-oic Acid Methyl Ester; Methyl (5Z,13E)-(15S)-9α,11α-Epidioxy-15-hydroxyprosta-5,13-dien-1-oate; Prostaglandin G2 Methyl Ester (common misnomer); Prostaglandin Endoperoxide Methyl Ester; 9,11-Epidioxy-15-hydroxyprostadienoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Prostaglandin H2 Methyl Ester is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing specific results for purity, related substances, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.