Description

5-Chloro-2-Fluoro-1-(Difluoromethyl)Benzene is a high-purity, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring chlorine, fluorine, and a difluoromethyl group, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group enhances bioavailability and stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display technologies.
• Organic Light-Emitting Diodes (OLEDs): Employed in the creation of specialized electron-transport or host materials for high-efficiency displays and lighting.
• Advanced Polymer Chemistry: Acts as a monomer or modifier to introduce fluorine into polymers, improving their chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A versatile building block for medicinal chemistry, facilitating structure-activity relationship (SAR) studies and the exploration of new chemical spaces.

Basic Information

Product Name	5-Chloro-2-Fluoro-1-(Difluoromethyl)Benzene
CAS No.	63878-72-8
Molecular Formula	C7H4ClF3
Molecular Weight	180.55 g/mol
Synonyms	1-Chloro-4-(difluoromethyl)-2-fluorobenzene; 2-Fluoro-5-chloro-α,α-difluorotoluene; 5-Chloro-2-fluoro-α,α-difluorotoluene; Benzene, 5-chloro-2-fluoro-1-(difluoromethyl)-; (Difluoromethyl)-5-chloro-2-fluorobenzene; 2-Fluoro-5-chlorobenzylidene difluoride
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-Fluoro-1-(Difluoromethyl)Benzene is produced and tested under a strict quality management system. We guarantee high chemical purity and consistency, with comprehensive analytical testing including GC, HPLC, and NMR to verify identity and assay. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.