Description

13,14-Dihydro-16-Phenyl-ω-Tetranorprostaglandin E2 CAS NO 63814-25-5 is a synthetic prostaglandin E2 (PGE2) analog, specifically engineered as a tetranor derivative with a phenyl substitution at the 16-position. This structural modification is critical for enhancing metabolic stability and receptor selectivity, making it a valuable research-grade biochemical. It is primarily utilized in advanced pharmaceutical research and development, particularly for studying prostaglandin-mediated pathways, inflammation, and smooth muscle function. This compound serves as a key intermediate and reference standard for scientists in drug discovery and life sciences.

Application

• Pharmaceutical R&D Intermediate: Serves as a critical building block in the synthesis of novel prostaglandin-based therapeutics targeting inflammation, pain, and cardiovascular conditions.
• Biochemical Research: Used as a reference standard and tool compound for investigating the pharmacology and signaling pathways of prostaglandin E2 receptors (EP1-EP4).
• Cell Biology Studies: Applied in in vitro assays to study its effects on smooth muscle contraction, vasodilation, and inflammatory cytokine production.
• Metabolic Pathway Analysis: Employed to study the metabolism and stability of prostaglandin analogs, aiding in the design of drugs with improved pharmacokinetic profiles.
• Academic Research: A key reagent for universities and research institutes focusing on eicosanoid biology, reproductive physiology, and renal function.

Basic Information

Product Name	13,14-Dihydro-16-Phenyl-ω-Tetranorprostaglandin E2
CAS No.	63814-25-5
Molecular Formula	C23H32O5
Molecular Weight	388.50 g/mol
Synonyms	16-Phenyl-tetranor-PGE2; 13,14-Dihydro-16-phenyl-tetranor-prostaglandin E2; 16-Phenyl-13,14-dihydro-tetranor-PGE2; PGE2 tetranor phenyl analog; 16-Phenyl-ω-tetranor-PGE2; DH-16-Ph-ω-tetranor-PGE2; 11,15-Dihydroxy-16-phenyl-9-oxoprosta-5,13-dien-1-oic Acid (related structure descriptor).
EINECS	Contact for details

Quality Control

Every batch of 13,14-Dihydro-16-Phenyl-ω-Tetranorprostaglandin E2 is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity, meeting the exacting standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment to guarantee traceability and consistency for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep the container sealed in a dry, freezer-safe environment. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.