Description

(R)-8-Hydroxy Warfarin is a specific stereoisomer and key metabolite of the anticoagulant drug warfarin. This compound matters as a critical reference standard and intermediate in pharmaceutical research and development, particularly for studying warfarin's metabolism, pharmacokinetics, and stereoselective activity. It is essential for analytical laboratories, pharmaceutical manufacturers, and research institutions focused on cardiovascular drug development, bioanalytical method validation, and metabolic pathway studies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the quantitative and qualitative analysis of warfarin and its metabolites in drug substances and biological samples via HPLC, LC-MS, or GC-MS.
• Metabolite Research: Serves as a crucial metabolite in studies investigating the metabolic pathways, stereoselective disposition, and pharmacokinetic profile of warfarin.
• Drug Impurity Profiling: Employed as an impurity marker or degradation product in the quality control and stability testing of warfarin sodium active pharmaceutical ingredient (API) and finished dosage forms.
• Biochemical Research: Utilized in enzymatic studies, particularly those involving cytochrome P450 enzymes (e.g., CYP2C9), to understand the stereospecific hydroxylation of warfarin.
• Analytical Method Development: Acts as a key component in developing and validating sensitive chromatographic assays for the separation and detection of warfarin enantiomers and their hydroxylated derivatives.

Basic Information

Product Name	(R)-8-Hydroxy Warfarin
CAS No.	63740-77-2
Molecular Formula	C19H16O5
Molecular Weight	324.33 g/mol
Synonyms	(R)-8-Hydroxywarfarin; (R)-8-Hydroxy-3-(α-acetonylbenzyl)-4-hydroxycoumarin; 8-Hydroxywarfarin (R-enantiomer); 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one, (R)-; Warfarin, 8-hydroxy-, (R)-; (R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
EINECS	Contact for details

Quality Control

Our (R)-8-Hydroxy Warfarin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and strength, meeting the stringent requirements for pharmaceutical reference standards and research chemicals. A comprehensive Certificate of Analysis (COA) detailing results for assay, chiral purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.