Description

(R)-7-Hydroxy Warfarin CAS NO 63740-76-1 is a high-purity chiral metabolite of the anticoagulant drug warfarin, specifically the (R)-enantiomer hydroxylated at the 7-position. This compound is of critical importance as a reference standard and key intermediate in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It is essential for analytical laboratories, research institutions, and pharmaceutical companies focused on cardiovascular drug development, quality control, and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of warfarin metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Metabolic Pathway Research: A crucial tool for studying the stereoselective metabolism, pharmacokinetics, and pharmacodynamics of warfarin and related anticoagulants.
• Analytical Method Development: Serves as a critical standard for developing and validating robust analytical methods in bioanalytical and quality control laboratories.
• Drug Impurity Profiling: Employed to identify and quantify specific isomeric impurities in active pharmaceutical ingredient (API) batches of warfarin.
• Clinical Toxicology Studies: Used in research investigating warfarin overdose, drug-drug interactions, and individual metabolic variations.
• Synthesis Intermediate: Acts as a chiral building block for the synthesis of novel anticoagulant compounds or labeled analogs for tracer studies.

Basic Information

Product Name	(R)-7-Hydroxy Warfarin
CAS No.	63740-76-1
Molecular Formula	C19H16O6
Molecular Weight	340.33 g/mol
Synonyms	(R)-7-Hydroxywarfarin; 7-Hydroxywarfarin (R-enantiomer); (R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; 3-(α-Acetonylbenzyl)-4-hydroxycoumarin, 7-hydroxy derivative, (R)-; Warfarin, 7-hydroxy-, (R)-; 7-OH-Warfarin (R)
EINECS	Contact for details

Quality Control

Our (R)-7-Hydroxy Warfarin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from chiral HPLC, NMR, and mass spectrometry to confirm enantiomeric purity and chemical identity. Our quality commitment aligns with the standards expected for high-grade pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (R)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.