Description

2-Deoxycoformycin (Pentostatin) is a potent purine nucleoside analog and a highly specific, tight-binding inhibitor of adenosine deaminase (ADA). This mechanism of action makes it a critical compound for targeted biochemical research and therapeutic development. It is primarily utilized by pharmaceutical researchers, academic institutions, and manufacturers in the life sciences sector for oncology research, enzyme inhibition studies, and as a reference standard.

Application

• Oncology Research & Drug Development: As an active pharmaceutical ingredient (API) for the treatment of hairy cell leukemia and investigation into other lymphoproliferative disorders.
• Biochemical Research: As a specific and potent inhibitor of adenosine deaminase (ADA) for studying purine metabolism, immune function, and lymphocyte development.
• Reference Standard: For quality control and analytical method development in pharmaceutical laboratories, ensuring batch consistency and regulatory compliance.
• Cell Culture & In Vitro Studies: To modulate adenosine levels and investigate its effects on cell proliferation, apoptosis, and immune cell activity.
• Enzyme Kinetics Studies: For detailed mechanistic studies of ADA inhibition and its role in various metabolic pathways.

Basic Information

Product Name	2-Deoxycoformycin
CAS No.	63677-95-2
Molecular Formula	C11H16N4O4
Molecular Weight	268.27 g/mol
Synonyms	Pentostatin; (R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol; 2'-Deoxycoformycin; CI-825; PD-81565; NSC-218321; dCF; ADA Inhibitor
EINECS	Contact for details

Quality Control

Our 2-Deoxycoformycin is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure compliance with research and pharmaceutical standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or desiccated conditions upon opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.