Description

4-Trifluoromethanesulfonylbenzene-1-Sulfonyl Chloride is a highly reactive and versatile sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the electron-withdrawing trifluoromethanesulfonyl group and the reactive sulfonyl chloride moiety, enabling precise functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require a high-purity intermediate for constructing complex sulfonamide and sulfonate structures.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of novel sulfonamide-based active pharmaceutical ingredients (APIs), including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Functional Material Production: Building block for creating specialty polymers, liquid crystals, and advanced electrolytes for lithium-ion batteries.
• Chemical Research & Development: A valuable reagent in medicinal chemistry and process chemistry for introducing the sulfonyl group into complex molecular architectures.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of high-performance, light-fast dyes and functional pigments.

Basic Information

Product Name	4-Trifluoromethanesulfonylbenzene-1-Sulfonyl Chloride
CAS No.	63647-64-3
Molecular Formula	C7H4ClF3O4S2
Molecular Weight	308.68 g/mol
Synonyms	4-(Trifluoromethanesulfonyl)benzenesulfonyl Chloride; 1-(Trifluoromethanesulfonyl)-4-sulfonylchloride Benzene; p-(Trifluoromethylsulfonyl)benzenesulfonyl Chloride; 4-(Trifluoromethylsulfonyl)phenylsulfonyl Chloride; Benzene-1,4-disulfonyl Chloride, 1-Trifluoromethyl Derivative; TFSBC; 4-TFMS-Benzenesulfonyl Chloride
EINECS	Contact for details

Quality Control

Our production of 4-Trifluoromethanesulfonylbenzene-1-Sulfonyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and titration methods, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.