Description

Balanol is a naturally derived, potent and selective protein kinase C (PKC) and protein kinase A (PKA) inhibitor isolated from the fungus Verticillium balanoides. It serves as a critical pharmacological tool for studying signal transduction pathways and validating kinase-targeted therapeutics. Researchers in academic laboratories, biopharmaceutical R&D centers, and contract research organizations (CROs) rely on high-purity Balanol for mechanistic enzymology, assay development, and structure–activity relationship (SAR) studies. Balanol CAS NO 63590-19-2 is supplied under stringent quality controls to ensure batch-to-batch reproducibility and functional integrity.

Application

• Primary research reagent for kinase inhibition assays targeting PKCα, PKCβ, PKCγ, and PKA
• Tool compound in cell-based signaling studies, including apoptosis, proliferation, and differentiation pathways
• Reference standard for HPLC and LC-MS method validation in analytical laboratories
• Lead scaffold in medicinal chemistry programs for oncology and neurodegenerative disease targets
• Calibration material for enzyme activity quantification in high-throughput screening (HTS) platforms
• Component in biochemical assay kits for kinase profiling and inhibitor selectivity panels

Basic Information

Product Name	Balanol
CAS No.	63590-19-2
Molecular Formula	C35H42N4O10
Molecular Weight	678.73 g/mol
Synonyms	NSC 649890; PD 144861; 1-[2-(4-Hydroxyphenyl)ethyl]-3-[4-(hydroxymethyl)phenyl]urea derivative; (3R,4R,5R)-3,4,5-Trihydroxy-6-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2-carboxylic acid 4-[(2S,3R,4S,5S,6R)-3-acetamido-2-hydroxy-6-(hydroxymethyl)-4-methoxyoxan-4-yl]phenyl ester; Balanol A; Balanol B; Verticillium balanoides inhibitor
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch of Balanol is verified for identity (IR, 1H-NMR), purity (HPLC ≥98.5%), residual solvents (GC), heavy metals (<5 ppm), and microbiological limits (where applicable). Testing follows ICH Q2(R2) guidelines and aligns with ACS Reagent Grade specifications for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Single impurity ≤0.5%; Total impurities ≤1.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Solubility	Soluble in DMSO (≥10 mg/mL), methanol, and acetonitrile; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.