Description

Benzo[A]Pyrene-7,8-Diol-9,10-Epoxide is a highly reactive and critical metabolite of the environmental pollutant benzo[a]pyrene. This compound matters as a primary reference standard for toxicological research and analytical method development, enabling precise study of carcinogenic mechanisms. It is essential for researchers and quality control laboratories in the pharmaceutical, environmental monitoring, and chemical safety sectors who require high-purity analytical standards.

Application

• Toxicological Research Standard: Serves as a definitive metabolite standard for studying the metabolic activation pathways and DNA adduct formation of polycyclic aromatic hydrocarbons (PAHs).
• Analytical Method Development: Used as a certified reference material (CRM) for calibrating HPLC, GC-MS, and LC-MS/MS systems in environmental and biological monitoring.
• Biomarker Studies: Critical for quantifying exposure to benzo[a]pyrene by measuring this specific metabolite or its DNA adducts in biological samples.
• Carcinogenicity Testing: Employed in *in vitro* and *in vivo* assays to investigate the genotoxic and mutagenic effects of PAH exposure.
• Pharmaceutical Impurity Profiling: Used in the development and validation of methods to detect and quantify potentially genotoxic impurities in active pharmaceutical ingredients (APIs).
• Regulatory Compliance & Safety Assessment: Supports studies required for regulatory submissions (e.g., REACH, ICH M7) concerning the risk assessment of PAH-containing substances.

Basic Information

Product Name	Benzo[A]Pyrene-7,8-Diol-9,10-Epoxide
CAS No.	63528-87-0
Molecular Formula	C₂₀H₁₂O₃
Molecular Weight	300.31 g/mol
Synonyms	BPDE; Benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide; (+)-anti-Benzo[a]pyrene-7,8-diol-9,10-epoxide; anti-BPDE; 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; B[a]PDE; Benzo[a]pyrene diol epoxide
EINECS	Contact for details

Quality Control

Our Benzo[A]Pyrene-7,8-Diol-9,10-Epoxide is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analysis, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to support your compliance and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Solubility	Soluble in DMSO, Acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.