Description

4-tert-Butylphenylmagnesium Bromide is a highly reactive Grignard reagent, a critical organometallic intermediate for constructing complex organic molecules. Its primary value lies in enabling efficient carbon-carbon bond formation, specifically for introducing the sterically hindered 4-tert-butylphenyl group into target structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for synthesis and process development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring bulky aromatic substituents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where the tert-butylphenyl moiety enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine or N-heterocyclic carbene (NHC) ligands used in homogeneous catalysis.
• Advanced Material Precursor: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers for electronic and optoelectronic applications.
• Fine Chemical and Flavor/Fragrance Ingredient: Facilitates the synthesis of complex aromatic compounds used in specialty chemicals.
• Cross-Coupling Reactions: A vital reagent in Kumada, Negishi, and other transition-metal-catalyzed cross-coupling methodologies.

Basic Information

Product Name	4-tert-Butylphenylmagnesium Bromide
CAS No.	63488-10-8
Molecular Formula	C10H13BrMg
Molecular Weight	237.42 g/mol
Synonyms	(4-(tert-Butyl)phenyl)magnesium bromide; p-tert-Butylphenylmagnesium bromide; 1-tert-Butyl-4-magnesiobromobenzene; 4-(1,1-Dimethylethyl)phenylmagnesium bromide; Grignard reagent, p-tert-butylphenylmagnesium bromide; (4-tert-Butylphenyl)magnesium bromide; Magnesium, bromo[4-(1,1-dimethylethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 4-tert-Butylphenylmagnesium Bromide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm concentration (typically supplied as a solution in THF or diethyl ether), purity, and the absence of deleterious impurities. A comprehensive Certificate of Analysis (COA) detailing assay (by titration), residual solvents, and other critical parameters is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, hygroscopic (moisture-sensitive), and easily oxidized (store under inert atmosphere). For optimal stability and safety, store the sealed reagent bottle under a dry, inert atmosphere (argon or nitrogen) at recommended cold temperatures (e.g., 2-8°C or as specified on the label). Keep away from heat, sparks, open flames, and incompatible materials such as water, acids, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	0.5 M to 2.0 M in THF or Et2O (typical)
Assay (Titration)	≥ 95% (of stated concentration)
Identification (IR/NMR)	Conforms to structure
Water (Karl Fischer)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.