Description

2-(Trifluoromethyl)Pyrimidine-4,6(1H,5H)-Dione is a high-value fluorinated pyrimidine derivative, a key heterocyclic building block prized for its unique chemical reactivity and trifluoromethyl group. This compound matters for its critical role in the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the CF3 moiety is known to enhance metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Serves as a key building block for developing advanced herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its fluorinated heterocyclic structure.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling agent in the design of chemical probes and enzyme inhibitors for biological target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	2-(Trifluoromethyl)Pyrimidine-4,6(1H,5H)-Dione
CAS No.	63447-36-9
Molecular Formula	C5H3F3N2O2
Molecular Weight	180.09 g/mol
Synonyms	4,6-Dihydroxy-2-(trifluoromethyl)pyrimidine; 2-(Trifluoromethyl)-4,6-pyrimidinediol; 2-(Trifluoromethyl)uracil; 5H-Pyrimidine-4,6-dione, 2-(trifluoromethyl)-1,5-dihydro-; 1H-Pyrimidine-4,6-dione, 2-(trifluoromethyl)-5-hydroxy-; 2-Trifluoromethyl-1H,5H-pyrimidine-4,6-dione; 2-Trifluoromethylpyrimidine-4,6-diol
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Pyrimidine-4,6(1H,5H)-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is sensitive to fluoride/strong alkali; keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.