Description

Syn-Bpde CAS NO 63357-09-5 is a high-purity synthetic benzo[a]pyrene diol epoxide (BPDE) derivative, a critical reference standard and research chemical. This compound is essential for studying the mechanisms of carcinogenesis and DNA adduct formation, providing researchers with a reliable tool for toxicological and metabolic investigations. It is primarily utilized by analytical laboratories, academic research institutions, and pharmaceutical R&D departments focused on environmental toxicology, cancer research, and biomarker discovery.

Application

• Biomarker Research: Used as a definitive standard for the detection and quantification of BPDE-DNA adducts in biological samples, serving as a critical biomarker for polycyclic aromatic hydrocarbon (PAH) exposure.
• Toxicology Studies: Essential for in vitro and in vivo studies to understand the metabolic activation pathways and genotoxic effects of benzo[a]pyrene.
• Analytical Reference Standard: Provides a high-purity calibrant for analytical techniques such as HPLC, GC-MS, and LC-MS/MS in environmental and biological monitoring.
• Cancer Mechanism Research: Facilitates investigations into the molecular mechanisms of chemical carcinogenesis, particularly related to lung and skin cancers.
• Pharmaceutical Development: Employed in screening assays to evaluate the efficacy of potential chemopreventive agents or DNA repair modulators.
• Quality Control & Method Validation: Serves as a key component in the validation of analytical methods for PAH metabolite detection in regulatory and compliance testing.

Basic Information

Product Name	Syn-Bpde
CAS No.	63357-09-5
Molecular Formula	C20H12O3
Molecular Weight	300.31 g/mol
Synonyms	Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (anti); (+)-anti-BPDE; 7β,8α-Dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; anti-BPDE; BPDE; Benzo[a]pyrene diol epoxide; B[a]PDE; 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene
EINECS	Contact for details

Quality Control

Our Syn-Bpde CAS NO 63357-09-5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to ensure identity, purity, and stability. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes batch-specific data on assay purity and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, store desiccated at 2-8°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Solubility	Soluble in DMSO, Acetone
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.