Description

Pifithrin-α (Pftα) is a potent and selective small-molecule inhibitor of p53, a critical tumor suppressor protein. This compound is a vital research tool for studying cellular apoptosis, DNA damage response, and the role of p53 in various disease models. It is primarily utilized by researchers and scientists in the fields of oncology, neurobiology, and molecular biology for in vitro and in vivo studies.

Application

• Biomedical Research: A key reagent for investigating p53-mediated pathways in cancer, neurodegeneration, and ischemia-reperfusion injury.
• Apoptosis Studies: Used to inhibit p53-dependent apoptosis, allowing researchers to dissect the mechanisms of programmed cell death.
• Drug Discovery & Development: Serves as a chemical probe in high-throughput screening and target validation for novel therapeutic agents.
• Neuroprotection Research: Applied in models of stroke and neurodegenerative diseases to study the protective effects of transient p53 inhibition.
• Cell Culture & In Vitro Assays: Employed to modulate p53 activity in various cell lines to understand gene expression and signaling networks.
• Preclinical Animal Studies: Used in rodent models to evaluate the therapeutic potential of p53 pathway modulation.

Basic Information

Product Name	Pifithrin-α (Pftα)
CAS No.	63208-82-2
Molecular Formula	C16H14N2O3S
Molecular Weight	314.36 g/mol
Synonyms	PFTα; Pifithrin-α; Pifithrin alpha; 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone; Pifithrin-α hydrobromide (salt form precursor); p53 Inhibitor Pifithrin-α; PFT-alpha
EINECS	Contact for details

Quality Control

Our Pifithrin-α (Pftα) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.