Description

2-Iodobenzene-1-Sulfonyl Chloride is a versatile and highly reactive organoiodine building block, primarily valued for its role as a key sulfonylation reagent in advanced organic synthesis. Its core value proposition lies in enabling the efficient introduction of the 2-iodobenzenesulfonyl moiety, a crucial step in constructing complex molecules for pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists engaged in synthesizing novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of sulfonamide-based drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that incorporate sulfonyl groups for enhanced activity.
• Chemical Biology & Proteomics: Serves as a reactive handle for activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Material Science: Employed in the synthesis of specialized polymers and organic electronic materials requiring sulfonyl functionalization.
• Cross-Coupling Reactions: The iodine atom provides a site for further functionalization via metal-catalyzed cross-coupling, such as Suzuki or Sonogashira reactions.
• Sulfonylation Agent: Directly reacts with amines, alcohols, and organometallic reagents to form sulfonamides, sulfonate esters, and sulfones.

Basic Information

Product Name	2-Iodobenzene-1-Sulfonyl Chloride
CAS No.	63059-29-0
Molecular Formula	C6H4ClIO2S
Molecular Weight	302.52 g/mol
Synonyms	2-Iodobenzenesulfonyl Chloride; o-Iodobenzenesulfonyl Chloride; Benzenesulfonyl chloride, 2-iodo-; 1-Iodo-2-(chlorosulfonyl)benzene; 2-Iodo-1-chlorosulfonylbenzene; o-Iodophenylsulfonyl Chloride; 2-Iodophenylsulfonyl Chloride
EINECS	Contact for details

Quality Control

Our 2-Iodobenzene-1-Sulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.