Description

5,6Alpha-Dihydro Pgi2 is a stable synthetic analog of prostacyclin, a key bioactive lipid mediator. This compound is valued for its potent biological activity, particularly in modulating platelet aggregation and vascular tone. It serves as a critical pharmaceutical intermediate and research chemical for developing cardiovascular therapeutics and studying prostaglandin signaling pathways.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of advanced prostaglandin-based drugs targeting cardiovascular and pulmonary diseases.
• Biochemical Research: Essential tool for in vitro and in vivo studies of prostacyclin (PGI2) receptor (IP receptor) function and signal transduction.
• Platelet Aggregation Studies: Used as a reference standard in pharmacological assays to investigate anti-thrombotic and vasodilatory mechanisms.
• Vascular Biology Research: Applied in models to study endothelial cell function, vascular smooth muscle relaxation, and hypertension.
• Reference Standard: Serves as a high-purity analytical standard for quality control in pharmaceutical manufacturing and academic research.

Basic Information

Product Name	5,6Alpha-Dihydro Pgi2
CAS No.	62777-90-6
Molecular Formula	C20H32O5
Molecular Weight	352.47 g/mol
Synonyms	5,6-Dihydroprostacyclin; 5,6-Dihydro PGI2; 15(S)-15-Methyl-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dien-1-oic Acid; 5,6-Dihydroprostaglandin I2; 15-Methyl-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dien-1-oic Acid; Carbacyclin derivative; U-61,431F (developmental code name)
EINECS	Contact for details

Quality Control

Our 5,6Alpha-Dihydro Pgi2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.