Description

Gsk-3β Inhibitor Vi CAS NO 62673-69-2 is a potent and selective small molecule inhibitor targeting glycogen synthase kinase-3 beta (GSK-3β), a key enzyme involved in numerous cellular signaling pathways. This compound is a critical research tool for investigating the role of GSK-3β in diseases such as diabetes, neurodegenerative disorders, and cancer. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in drug discovery and biochemical pathway analysis.

Application

• Biochemical Research: A fundamental tool for studying Wnt/β-catenin, insulin, and other signaling pathways where GSK-3β acts as a regulatory kinase.
• Drug Discovery & Development: Serves as a reference compound and pharmacological probe in high-throughput screening (HTS) and lead optimization for novel therapeutics.
• Neurodegenerative Disease Research: Used in models of Alzheimer's disease, Parkinson's disease, and other tauopathies to explore GSK-3β inhibition as a potential therapeutic strategy.
• Metabolic Disorder Studies: Applied in diabetes and obesity research to investigate the enzyme's role in glycogen synthesis and glucose homeostasis.
• Oncology Research: Employed in cancer cell line studies to examine the effects of GSK-3β inhibition on cell proliferation, apoptosis, and tumor growth.
• Stem Cell Research: Facilitates the study of GSK-3β in cell fate determination, differentiation, and self-renewal processes.

Basic Information

Product Name	Gsk-3β Inhibitor Vi
CAS No.	62673-69-2
Molecular Formula	C16H12N2O2
Molecular Weight	264.28 g/mol
Synonyms	GSK-3 Inhibitor VI; 6-Bromoindirubin-3'-oxime; BIO; (2'Z,3'E)-6-Bromoindirubin-3'-oxime; 6-Bromoindirubin-3'-monoxime; GSK-3β Inhibitor VI; Axam; 6-BIO; 6-Br-IO
EINECS	Contact for details

Quality Control

Our Gsk-3β Inhibitor Vi is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container in a sealed secondary container with desiccant. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.