Description

Harringtonine is a naturally occurring alkaloid ester derived from the *Cephalotaxus* genus of evergreen trees. This compound is a potent and specific inhibitor of protein synthesis, making it a critical tool for biochemical and pharmacological research. It is primarily utilized by researchers and developers in the life sciences sector for studying cellular mechanisms and developing novel therapeutic agents. Harringtonine CAS NO 62624-24-2 is supplied as a high-purity reference standard to ensure experimental accuracy and reproducibility.

Application

• Biomedical Research: Used as a selective inhibitor of eukaryotic protein synthesis to study gene expression, cell cycle regulation, and apoptosis.
• Anticancer Agent Screening: Serves as a reference compound and positive control in assays designed to discover and evaluate new chemotherapeutic agents.
• Mechanistic Studies: Employed to investigate the function of ribosomes and the initiation phase of protein translation in various cell lines.
• Pharmaceutical Development: Acts as a key intermediate or reference standard in the R&D of novel oncology drugs and targeted therapies.
• Academic Research: Utilized in university and institutional laboratories for fundamental research in molecular biology and biochemistry.
• Quality Control: Functions as a certified reference material (CRM) for the quality assurance of related pharmaceutical products and research reagents.

Basic Information

Product Name	Harringtonine
CAS No.	62624-24-2
Molecular Formula	C28H37NO9
Molecular Weight	531.60 g/mol
Synonyms	NSC 143007; Harringtonine; (+)-Harringtonine; Cephalotaxine 4-methyl 2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester); Homoharringtonine precursor; Cephalotaxus alkaloid
EINECS	Contact for details

Quality Control

Our Harringtonine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to relevant guidelines for research-grade chemical standards to support the integrity of your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.