Description

3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propane-1-sulfonyl chloride is a high-purity, reactive chemical intermediate featuring a phthalimide-protected amine linked to a sulfonyl chloride functional group. This compound matters for its role as a versatile building block in the synthesis of complex molecules, enabling the introduction of sulfonamide linkages under mild conditions. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-containing drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides where the sulfonamide moiety contributes to biological activity.
• Peptide Modification: Employed to selectively sulfonylate amine groups on amino acids or peptides for structure-activity relationship (SAR) studies.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers with specific thermal or chemical resistance properties.
• Material Science Research: Utilized in the surface functionalization of nanomaterials and the creation of advanced organic frameworks.
• Bioconjugation: Facilitates the attachment of reporter molecules or drugs to proteins, antibodies, or other biomolecules for diagnostic and therapeutic applications.

Basic Information

Product Name	3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propane-1-sulfonyl chloride
CAS No.	62605-69-0
Molecular Formula	C11H10ClNO4S
Molecular Weight	287.72 g/mol
Synonyms	2-(3-Chlorosulfonylpropyl)isoindoline-1,3-dione; 3-(1,3-Dioxoisoindolin-2-yl)propane-1-sulfonyl chloride; N-(3-Chlorosulfonylpropyl)phthalimide; Phthalimidopropanesulfonyl chloride; 1,3-Dioxo-2-(3-sulfonylchloridopropyl)isoindoline; PSC
EINECS	Contact for details

Quality Control

Our 3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propane-1-sulfonyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.