Description

(2E,5E)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,R)-4-Phenoxy-3-Hydroxy-1-Butenyl]Cyclopentan-1α-Yl]-2,5-Heptadienoic Acid Methyl Ester is a high-purity synthetic prostaglandin intermediate of significant importance in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of complex bioactive molecules, enabling precise control over stereochemistry and biological activity. It is primarily required by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of novel therapeutics targeting inflammation, cardiovascular function, and reproductive health.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of prostaglandin analogs and related prostanoid receptor modulators.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and the creation of new chemical entities (NCEs).
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Biochemical Research: Employed in vitro and in vivo studies to investigate the physiological roles and signaling pathways of prostaglandins.
• Process Chemistry: Utilized for scaling up and optimizing synthetic routes for prostaglandin-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2E,5E)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,R)-4-Phenoxy-3-Hydroxy-1-Butenyl]Cyclopentan-1α-Yl]-2,5-Heptadienoic Acid Methyl Ester
CAS No.	62524-94-1
Molecular Formula	C23H30O6
Molecular Weight	402.48 g/mol
Synonyms	Methyl (2E,5E)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-4-Phenoxy-3-hydroxy-1-buten-1-yl]cyclopentyl]-2,5-heptadienoate; Prostaglandin F2α Methyl Ester Derivative; 9,11,15-Trihydroxy-17-phenoxy-18,19,20-trinorprosta-5,13-dien-1-oic Acid Methyl Ester; PGF2α Analogue Intermediate; 11-Deoxy-16-phenoxy-17,18,19,20-tetranor-PGF2α Methyl Ester; (5Z,13E)-(9R,11R,15R)-9,11,15-Trihydroxy-16-phenoxy-17,18,19,20-tetranorprosta-5,13-dien-1-oic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (2E,5E)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,R)-4-Phenoxy-3-Hydroxy-1-Butenyl]Cyclopentan-1α-Yl]-2,5-Heptadienoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assays to confirm stereochemical integrity, ensuring it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. For long-term storage, keep the container sealed in a dry, cold environment. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.