Description

(Z)-7-[(1R)-2β-[(E,S)-5-(4-Chlorophenyl)-3-Hydroxy-5-Oxo-1-Pentenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester is a high-purity, complex prostaglandin analog intermediate of significant importance in advanced pharmaceutical synthesis. This compound serves as a critical building block for the development of novel therapeutic agents, particularly in the fields of ophthalmology and cardiovascular medicine. It is essential for research institutions and pharmaceutical manufacturers engaged in the synthesis of prostaglandin-based drugs, where precise stereochemistry and high purity are non-negotiable for efficacy and regulatory approval.

Application

• Key Intermediate in Prostaglandin Analog Synthesis: Serves as a crucial precursor in the multi-step synthesis of potent prostaglandin F2α (PGF2α) analogs and related compounds.
• Ophthalmic Drug Development: Used in research and production of active pharmaceutical ingredients (APIs) for glaucoma and ocular hypertension treatments, such as latanoprost and travoprost analogs.
• Pharmaceutical Research & Development: A vital tool for medicinal chemists exploring structure-activity relationships (SAR) and developing new prostaglandin receptor agonists or antagonists.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling up production for clinical trial materials and commercial manufacturing.
• Reference Standard: Can be utilized as a high-purity analytical reference standard for quality control and method validation in API production.
• Biochemical Research: Applied in studies investigating prostaglandin pathways, receptor binding, and cellular signaling mechanisms.

Basic Information

Item	Details
Product Name	(Z)-7-[(1R)-2β-[(E,S)-5-(4-Chlorophenyl)-3-Hydroxy-5-Oxo-1-Pentenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester
CAS No.	62429-46-3
Molecular Formula	C24H29ClO6
Molecular Weight	448.94 g/mol
Synonyms	Methyl (5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3S)-3-Hydroxy-5-(4-chlorophenyl)-5-oxo-1-penten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoate; 15-Deoxy-16-hydroxy-16-(4-chlorophenacyl)-9-oxoprosta-5,13-dien-1-oic Acid Methyl Ester; Prostaglandin F2α Chlorophenacyl Ester Methyl Ester; Latanoprost Related Compound; Travoprost Intermediate; 9-Oxo-11α,15α-dihydroxy-16-(4-chlorophenacyl)-5-cis,13-trans-prostadienoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (Z)-7-[(1R)-2β-[(E,S)-5-(4-Chlorophenyl)-3-Hydroxy-5-Oxo-1-Pentenyl]-3α,5α-Dihydroxycyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral assays to confirm stereochemical integrity, ensuring it meets the exacting standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Store in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.