Description

7-Hydroxytrifluoperazine is a key pharmaceutical intermediate and metabolite of the antipsychotic agent trifluoperazine. This compound is of significant importance for research and development in neuropharmacology and analytical chemistry. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for drug metabolism studies, impurity profiling, and as a reference standard.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity quantification of trifluoperazine in drug substances and finished products.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic pathways and pharmacokinetics of trifluoperazine.
• Analytical Method Development: Serves as a critical component in developing and validating HPLC, LC-MS, and other chromatographic methods for antipsychotic drug analysis.
• Impurity Profiling: Employed to monitor and control the quality of trifluoperazine active pharmaceutical ingredients (APIs) by quantifying related substances.
• Biochemical Research: Used in studies exploring the mechanism of action and receptor binding profiles of phenothiazine-derived neuroleptics.

Basic Information

Product Name	7-Hydroxytrifluoperazine
CAS No.	62267-37-2
Molecular Formula	C21H24F3N3OS
Molecular Weight	423.50 g/mol
Synonyms	10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazin-7-ol; Trifluoperazine, 7-hydroxy-; 7-Hydroxy-2-trifluoromethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine; 7-OH-Trifluoperazine; Trifluoperazine 7-Hydroxy Metabolite; Trifluoperazine Hydroxy Metabolite; 7-Hydroxy Trifluoperazine
EINECS	Contact for details

Quality Control

Our 7-Hydroxytrifluoperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of related substances. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or quality control requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.