Description

Triciribine is a potent and selective small-molecule inhibitor of the AKT (Protein Kinase B) signaling pathway. This compound matters significantly for researchers and developers in oncology and metabolic disease studies, as it directly targets a key regulator of cell survival, proliferation, and growth. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel targeted cancer therapies and investigating cellular signaling mechanisms.

Application

• Biomedical Research: A critical tool for studying the role of the PI3K/AKT/mTOR pathway in cancer biology, cell signaling, and apoptosis.
• Oncology Drug Discovery: Used as a reference standard and pharmacological probe in high-throughput screening and preclinical studies for developing new anticancer agents.
• Mechanistic Studies: Employed to elucidate the function of AKT isoforms (AKT1, AKT2, AKT3) in various disease models, including metabolic disorders and neurological conditions.
• Combination Therapy Research: Investigated for potential synergistic effects when used alongside chemotherapy, radiotherapy, or other targeted therapies to overcome drug resistance.
• Biochemical Assay Development: Serves as a positive control in kinase inhibition assays and other in vitro diagnostic test development.

Basic Information

Product Name	Triciribine
CAS No.	61966-08-3
Molecular Formula	C₂₀H₂₆N₆O₄
Molecular Weight	414.46 g/mol
Synonyms	API-2; VQD-002; NSC 154020; Tricyclic nucleoside; 6-Amino-4-[[4-(aminocarbonyl)phenyl]amino]-1,4-dihydro-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-(2-phenylethyl)pyrazolo[3,4-b]pyridine-5-carbonitrile; TCBN; AKT Inhibitor IV
EINECS	Contact for details

Quality Control

Our Triciribine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.