Description

Vinblastine N'B-Oxide is a semi-synthetic derivative of the potent vinca alkaloid vinblastine, characterized by the oxidation of its N'B nitrogen. This modification is of significant interest in pharmaceutical research for exploring structure-activity relationships and developing novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in anticancer drug discovery and development.

Application

• Pharmaceutical Reference Standard: Serves as a critical analytical standard for the identification, purity assessment, and quantification of vinblastine and related compounds in research and quality control laboratories.
• Anticancer Research: Used as a key intermediate or probe molecule in biochemical and pharmacological studies to investigate the mechanisms of action of vinca alkaloids and their derivatives.
• Metabolite Studies: Employed in the study of vinblastine metabolism, helping to identify and characterize oxidative metabolic pathways in preclinical models.
• Medicinal Chemistry: Acts as a building block or precursor for the synthesis of new chemical entities with potential antitumor activity, aiming to improve efficacy or reduce side effects.
• Biochemical Assay Development: Utilized in the development and validation of high-throughput screening assays targeting tubulin polymerization and microtubule dynamics.

Basic Information

Product Name	Vinblastine N'B-Oxide
CAS No.	61936-68-3
Molecular Formula	C46H58N4O10
Molecular Weight	826.98 g/mol
Synonyms	Vincaleukoblastine N'B-Oxide; Vinblastine N-Oxide; 3',4'-Didehydro-4'-deoxy-8'-norvincaleukoblastine N'B-Oxide; Catharanthine, derivative; VLB N'B-Oxide
EINECS	Contact for details

Quality Control

Our Vinblastine N'B-Oxide is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.