Description

6-Hydroxy Debrisoquin is a key metabolite and reference standard of the antihypertensive drug debrisoquine, primarily used in pharmacological and metabolic research. This compound is critical for studying the cytochrome P450 2D6 (CYP2D6) enzyme pathway, which is essential for understanding individual variations in drug metabolism and efficacy. It serves as an indispensable analytical standard for pharmaceutical R&D laboratories, clinical research organizations, and diagnostic manufacturers focused on pharmacogenetics and personalized medicine.

Application

• Pharmacogenetics Research: Used as a reference standard to study the CYP2D6 enzyme polymorphism and its impact on drug metabolism.
• Clinical Diagnostic Assays: Serves as a critical calibrant and control in in-vitro diagnostic (IVD) kits for determining patient metabolizer status.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to investigate the metabolic pathways of debrisoquine and related compounds.
• Pharmaceutical Impurity Profiling: Acts as a known impurity standard in the quality control of debrisoquine active pharmaceutical ingredient (API) and related formulations.
• Biomarker Analysis: Utilized in analytical method development and validation (e.g., HPLC, LC-MS/MS) for the quantitative determination of 6-hydroxydebrisoquin in biological matrices.
• Academic & Institutional Research: Supports fundamental research in pharmacology, toxicology, and personalized medicine at universities and research institutes.

Basic Information

Product Name	6-Hydroxy Debrisoquin
CAS No.	61911-79-3
Molecular Formula	C12H15N3O2
Molecular Weight	233.27 g/mol
Synonyms	6-Hydroxydebrisoquine; 1,2,3,4-Tetrahydro-6-hydroxy-2-isoquinolinecarboximidamide; 6-OH-Debrisoquine; Debrisoquin 6-Hydroxy Metabolite; 6-Hydroxy Debrisoquine Sulfate (Salt); 4-Hydroxydebrisoquin (related isomer); CYP2D6 Metabolite Standard
EINECS	Contact for details

Quality Control

Every batch of 6-Hydroxy Debrisoquin is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for research and diagnostic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay, related substances, and residual solvents. Our quality commitment supports compliance with relevant pharmacopeial and ISO standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.