Description

Prostaglandins I2 Methyl Ester is a chemically stabilized analog of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This methyl ester derivative offers enhanced stability for research and development applications, facilitating easier handling and storage compared to the native compound. It is a critical intermediate and reference standard for pharmaceutical research targeting cardiovascular diseases, pulmonary hypertension, and thrombosis.

Application

• Pharmaceutical R&D Intermediate: Serves as a key synthetic precursor in the development of novel prostacyclin-based therapeutics.
• Biochemical Research: Used as a reference standard in studies investigating vascular biology, platelet function, and smooth muscle relaxation.
• Cell Signaling Studies: Applied in vitro to study the role of the IP receptor pathway and cyclic AMP-mediated cellular responses.
• Analytical Standard: Employed as a high-purity calibrant in HPLC, LC-MS, and other analytical methods for quality control and metabolic studies.
• Probe Compound: Utilized to explore the structure-activity relationships (SAR) of prostacyclin analogs for drug discovery.

Basic Information

Product Name	Prostaglandins I2 Methyl Ester
CAS No.	61799-74-4
Molecular Formula	C₂₂H₃₄O₆
Molecular Weight	394.50 g/mol
Synonyms	PGI2 Methyl Ester; Prostacyclin Methyl Ester; 5,6-Didehydro-6,9-epoxy-PGF1α Methyl Ester; (5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic Acid Methyl Ester; Epoprostenol Methyl Ester; Iloprost Related Compound; U-53217A; 6,9α-Epoxy-11α,15α-dihydroxy-5,13-prostadienoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Prostaglandins I2 Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent research-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.