Description

2-Trifluoromethylpyrazine is a high-value fluorinated heterocyclic building block, distinguished by the presence of a reactive trifluoromethyl group on the pyrazine ring. This unique structure makes it a critical intermediate for synthesizing advanced molecules with enhanced properties like metabolic stability and lipophilicity. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, such as components for OLEDs or conductive polymers, due to its electron-deficient aromatic system.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and introducing fluorine atoms into complex molecular architectures.
• Fine Chemical Production: Intermediate for manufacturing dyes, flavors, and fragrances that require specific fluorinated motifs.

Basic Information

Product Name	2-Trifluoromethylpyrazine
CAS No.	61655-67-2
Molecular Formula	C5H3F3N2
Molecular Weight	148.09 g/mol
Synonyms	Pyrazine, 2-(trifluoromethyl)-; 2-(Trifluoromethyl)pyrazine; α,α,α-Trifluoro-2-pyrazinemethane; Trifluoromethylpyrazine; 2-TFMP; 2-CF3-Pyrazine
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethylpyrazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.