Description

(R)-N'-Nitrosonornicotine is a chiral nitrosamine derivative of nornicotine, a key alkaloid found in tobacco. This compound is of significant interest in analytical chemistry and toxicological research due to its role as a potential biomarker and a specific stereoisomer of a tobacco-specific nitrosamine (TSN). It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in substance analysis, carcinogenicity studies, and the development of detection methodologies for nitrosamine impurities.

Application

• Analytical Reference Standard: Serves as a high-purity certified standard for the qualitative and quantitative analysis of tobacco-specific nitrosamines (TSNAs) in various matrices.
• Toxicological Research: Used in studies investigating the metabolism, distribution, and carcinogenic mechanisms of chiral nitrosamine compounds.
• Method Development & Validation: Critical for developing and validating sensitive analytical methods, such as LC-MS/MS and GC-MS, for nitrosamine impurity detection in pharmaceuticals and consumer products.
• Biomarker Studies: Employed in research aiming to understand human exposure to tobacco products and related nitrosamines.
• Chemical Synthesis Intermediate: Acts as a specialized chiral building block or precursor in organic synthesis for research purposes.
• Regulatory Compliance Testing: Supports testing protocols to ensure compliance with stringent regulations regarding nitrosamine limits in pharmaceuticals (e.g., per ICH M7(R2) guidelines) and tobacco products.

Basic Information

Product Name	(R)-N'-Nitrosonornicotine
CAS No.	61601-78-3
Molecular Formula	C9H11N3O
Molecular Weight	177.20 g/mol
Synonyms	(R)-NNN; (R)-N'-Nitrosoanatabine; (R)-1-Methyl-2-(3-pyridyl)-1-nitrosopyrrolidine; (R)-N-Nitrosonornicotine; (R)-Nornicotine N-nitrosamine; (R)-TSNA; (R)-Tobacco-specific nitrosamine; (R)-Enantiomer of N'-Nitrosonornicotine
EINECS	Contact for details

Quality Control

Our (R)-N'-Nitrosonornicotine is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure identity, potency, and purity meet the exacting standards required for research and analytical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	Yellow to light brown solid or oil
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98% (R)-enantiomer
Water Content (KF)	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.