Description

15-Keto Prostaglandin A1 is a specialized oxidized metabolite of prostaglandin A1, distinguished by its unique keto group at the 15-position. This compound is of significant interest in biochemical and pharmacological research due to its role as a potential signaling molecule and its distinct biological activity profile compared to other prostaglandins. It serves as a critical reference standard and intermediate for researchers in pharmaceutical development, analytical chemistry, and life sciences, particularly those investigating eicosanoid pathways, inflammation, and cellular regulation.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for the quantification and qualification of prostaglandin metabolites in drug discovery and development processes.
• Biochemical Research: A key tool for studying the metabolism, biological activity, and signaling pathways of eicosanoids in in vitro and ex vivo models.
• Metabolite Analysis: Essential for method development and validation in analytical techniques like LC-MS/MS and HPLC for profiling prostaglandin derivatives in complex biological matrices.
• Enzyme Substrate/Inhibitor Studies: Employed in assays to investigate the function and kinetics of enzymes involved in prostaglandin synthesis and degradation, such as dehydrogenases.
• Cell Signaling Studies: Utilized to explore the role of specific prostaglandin metabolites in cellular processes, including inflammation, apoptosis, and proliferation.

Basic Information

Product Name	15-Keto Prostaglandin A1
CAS No.	61600-67-7
Molecular Formula	C₂₀H₃₀O₅
Molecular Weight	350.45 g/mol
Synonyms	15-Keto-PGA1; 15-Oxoprostaglandin A1; 15-Oxo-PGA1; (5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-5-oxocyclopentyl]-5-heptenoic Acid; 15-Ketoprostaglandin A1; PGA1, 15-keto-; 15-Keto-PGA₁
EINECS	Contact for details

Quality Control

Our 15-Keto Prostaglandin A1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical methods including HPLC and mass spectrometry. We adhere to relevant quality guidelines for research chemicals to guarantee reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.