Description

α-Hydroxy Flurbiprofen CAS NO 61466-95-3 is a key pharmaceutical intermediate and metabolite of the non-steroidal anti-inflammatory drug (NSAID) flurbiprofen. This compound is of significant value in the research and development of new therapeutic agents and analytical reference standards. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism studies, pharmacokinetic research, and impurity profiling.

Application

• Pharmaceutical Intermediate: Critical synthesis building block for the development of novel NSAID derivatives and prodrugs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Metabolite Studies: Essential for in-vitro and in-vivo drug metabolism and pharmacokinetic (DMPK) research to understand flurbiprofen's biotransformation pathways.
• Impurity Profiling: Serves as a specified impurity standard to ensure the purity and safety of flurbiprofen active pharmaceutical ingredient (API) batches according to ICH guidelines.
• Biochemical Research: Employed in studies investigating cyclooxygenase (COX) enzyme inhibition mechanisms and structure-activity relationships (SAR).

Basic Information

Product Name	α-Hydroxy Flurbiprofen
CAS No.	61466-95-3
Molecular Formula	C15H13FO3
Molecular Weight	260.26 g/mol
Synonyms	2-Hydroxy-2-fluoro-α-methyl-[1,1'-biphenyl]-4-acetic Acid; 2-(2-Fluoro-4-hydroxy-4-methylbiphenyl-4-yl)propanoic Acid; 2-(3-Fluoro-4-phenylphenyl)lactic Acid; Flurbiprofen Metabolite I; Flurbiprofen Hydroxy Metabolite; (±)-2-(2-Fluoro-4-hydroxy-4-methyl[1,1'-biphenyl]-4-yl)propanoic Acid; α-Hydroxyflurbiprofen
EINECS	Contact for details

Quality Control

Our α-Hydroxy Flurbiprofen is manufactured under a quality management system and undergoes rigorous analytical testing to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing parameters such as assay, related substances, and identification. Specifications are aligned with industry standards for pharmaceutical intermediates and reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.