Description

9-Deoxy-9-Methylene-16,16-Dimethyl Prostaglandin E2 is a synthetic prostaglandin analog, a key intermediate in advanced pharmaceutical research and development. This compound is valued for its structural specificity, enabling the study and modulation of prostaglandin-mediated biological pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics targeting inflammation, ocular pressure, and reproductive health.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel prostaglandin-based drugs.
• Biochemical Research: Used as a reference standard and tool compound for studying prostaglandin receptors (EP receptors) and their signaling mechanisms.
• Ophthalmic Drug Development: Investigated for potential applications in glaucoma treatment due to its structural relation to latanoprost analogs.
• Inflammation Studies: Employed in preclinical research to understand and modulate inflammatory responses.
• Process Chemistry: Used in scaling up synthetic routes for prostaglandin derivatives under controlled GMP-like conditions.

Basic Information

Product Name	9-Deoxy-9-Methylene-16,16-Dimethyl Prostaglandin E2
CAS No.	61263-35-2
Molecular Formula	C24H38O5
Molecular Weight	406.56 g/mol
Synonyms	9-Deoxy-9-methylene-16,16-dimethyl-PGE2; 16,16-Dimethyl-9-deoxy-9-methylene Prostaglandin E2; 9-Methylene-9-deoxy-16,16-dimethylprostaglandin E2; 9-Methylene-9-deoxy-16,16-dimethyl-PGE2; U-46619 (Note: U-46619 is a closely related thromboxane A2 mimetic; this compound is a structural analog); Prostaglandin E2 analog; 9-Deoxy-δ9-PGE2, 16,16-dimethyl derivative
EINECS	Contact for details

Quality Control

Our 9-Deoxy-9-Methylene-16,16-Dimethyl Prostaglandin E2 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation (NMR, IR) to ensure it meets the stringent requirements for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Store in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.