Description

4-Chloro-2,3,5,6-Tetrafluorobenzylchloride is a versatile and highly functionalized aromatic building block, critical for introducing the tetrafluorobenzyl moiety into complex molecular architectures. Its value lies in its dual reactive sites, which enable precise synthesis of advanced intermediates for high-performance materials and active pharmaceutical ingredients. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates where the tetrafluorobenzyl group can modulate lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms to improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, where fluorine substitution enhances thermal stability and optical properties.
• Polymer Modification: Employed to introduce fluorinated benzyl groups into polymer chains, improving chemical resistance, surface properties, and durability of high-performance plastics and coatings.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex, polyfluorinated biaryl systems.
• Ligand & Catalyst Development: Used to synthesize specialized fluorinated ligands for catalysis, which can lead to more efficient and selective industrial chemical processes.

Basic Information

Product Name	4-Chloro-2,3,5,6-Tetrafluorobenzylchloride
CAS No.	60903-83-5
Molecular Formula	C7H2Cl2F4
Molecular Weight	244.99 g/mol
Synonyms	1-(Chloromethyl)-4-chloro-2,3,5,6-tetrafluorobenzene; 2,3,5,6-Tetrafluoro-4-chlorobenzyl Chloride; α,4-Dichloro-α,α,2,3,5,6-hexafluorotoluene; 4-Chloro-2,3,5,6-tetrafluorobenzyl Chloride; Benzene, 1-(chloromethyl)-4-chloro-2,3,5,6-tetrafluoro-; p-Chloro-α,α,2,3,5,6-hexafluorotoluene; Tetrafluorobenzylchloride derivative
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,3,5,6-Tetrafluorobenzylchloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The compound is compatible with standard organic solvents but is moisture-sensitive; containers should be kept sealed under an inert atmosphere when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.