Description

4-Chloro-2,3,5,6-Tetrafluorotoluene is a versatile fluorinated aromatic building block of significant industrial importance. Its unique structure, featuring both chlorine and fluorine substituents, makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs). This compound is essential for manufacturers in the agrochemical, pharmaceutical, and specialty chemical sectors seeking to develop novel compounds with enhanced properties. Its reactivity profile allows for selective functionalization, enabling the creation of complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, leveraging the metabolic stability and lipophilicity imparted by fluorine atoms.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine-chlorine combination improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Negishi) and nucleophilic aromatic substitution to introduce the tetrafluorotoluene moiety into complex molecules.
• Surface Active Agents & Coatings: Used in the formulation of high-performance surfactants and coatings that require oil and water repellency (fluorosurfactants).

Basic Information

Product Name	4-Chloro-2,3,5,6-Tetrafluorotoluene
CAS No.	60903-82-4
Molecular Formula	C7H3ClF4
Molecular Weight	198.55 g/mol
Synonyms	1-Chloro-2,3,5,6-tetrafluoro-4-methylbenzene; 2,3,5,6-Tetrafluoro-4-chlorotoluene; 4-Chlorotetrafluorotoluene; p-Chlorotetrafluorotoluene; Toluene, 4-chloro-2,3,5,6-tetrafluoro-; α,α,α,4-Tetrachlorotoluene (incorrect but sometimes listed); Perfluorochlorotoluene (common industry name)
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,3,5,6-Tetrafluorotoluene is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent composition. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our production adheres to cGMP principles where applicable, ensuring reliability for critical applications in pharmaceutical and agrochemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and strong oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability, though short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to reference spectrum
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Density (at 20°C)	~1.55 g/cm³
Boiling Point	~150-155°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.