Description

Acetaminophen-D3 CAS NO 60902-28-5 is a stable isotope-labeled analog of the widely used analgesic and antipyretic drug, acetaminophen. This deuterated compound is an essential internal standard for accurate quantification in analytical chemistry, particularly in mass spectrometry, ensuring reliable and reproducible results. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities for drug metabolism and pharmacokinetic (DMPK) studies, bioanalytical method development, and quality control.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for precise quantification of acetaminophen in biological matrices (plasma, serum, urine) during bioanalytical studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry to track and measure the parent drug and its metabolites in preclinical and clinical research.
• Pharmaceutical Quality Control: Serves as a reference standard in the assay and impurity profiling of acetaminophen in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Forensic and Clinical Toxicology: Enables accurate measurement of acetaminophen levels in cases of overdose or therapeutic drug monitoring.
• Stable Isotope Labeling Studies: Utilized in research investigating the metabolic pathways and environmental fate of acetaminophen.
• Method Development and Validation: An indispensable tool for developing, optimizing, and validating robust analytical methods in compliance with ICH and FDA guidelines.

Basic Information

Product Name	Acetaminophen-D3
CAS No.	60902-28-5
Molecular Formula	C8H6D3NO2
Molecular Weight	154.18 g/mol
Synonyms	Paracetamol-D3; 4'-Hydroxyacetanilide-D3; N-(4-Hydroxyphenyl)acetamide-D3; APAP-D3; 4-Acetamidophenol-D3; Deuterated Acetaminophen; [2H3]-Acetaminophen; N-Acetyl-p-aminophenol-D3
EINECS	Contact for details

Quality Control

Our Acetaminophen-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical purity. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic purity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.