Description

Pifithrin-α, p-Nitro, Cyclic is a potent and selective chemical inhibitor of p53-mediated apoptosis and cell cycle arrest. This compound is a critical research tool for investigating the p53 tumor suppressor pathway and its role in cellular stress responses. It is primarily utilized by researchers in pharmaceutical development, oncology research, and molecular biology to study mechanisms of cell death and survival.

Application

• Biochemical Research: A key reagent for studying the biological functions and signaling pathways of the p53 protein.
• Oncology & Cancer Biology: Used to investigate p53's role in tumor suppression, chemotherapy-induced apoptosis, and potential therapeutic strategies.
• Neuroprotection Studies: Applied in research models to examine p53 inhibition as a potential approach for mitigating neuronal cell death.
• Cardioprotection Research: Utilized in experimental models to explore the effects of p53 pathway modulation on ischemia-reperfusion injury.
• Cell Culture & In Vitro Assays: Serves as a selective inhibitor to dissect p53-dependent from p53-independent cellular processes.
• Drug Discovery & Development: Acts as a reference compound and pharmacological tool in screening and validating new therapeutic candidates targeting the p53 pathway.

Basic Information

Product Name	Pifithrin-α, p-Nitro, Cyclic
CAS No.	60477-38-5
Molecular Formula	C16H13N3O3S
Molecular Weight	327.36 g/mol
Synonyms	Pifithrin-α p-Nitro Cyclic; PFT-α, p-Nitro Cyclic; 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-(4-nitrophenyl)ethanone; Pifithrin-α Cyclic p-Nitro Derivative; p53 Inhibitor Pifithrin-α Nitro Cyclic; PFTα (p-Nitro, Cyclic); 60477-38-5; Pifithrin Alpha p-Nitro Cyclic Form
EINECS	Contact for details

Quality Control

Our Pifithrin-α, p-Nitro, Cyclic is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals to guarantee reliable and reproducible experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.