Description

Cyclic-Pifithrin-Alpha CAS NO 60477-34-1 is a potent and selective small-molecule inhibitor of p53-dependent apoptosis, widely recognized for its critical role in biochemical and pharmacological research. This compound is essential for studying cellular stress responses, neuroprotection, and the mechanisms of programmed cell death. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic research sectors for drug discovery and mechanistic studies.

Application

• Biochemical Research: Used as a key tool compound to inhibit p53-mediated apoptosis in cell culture studies.
• Neuroprotection Studies: Investigated for its potential to protect neurons from ischemia-induced cell death in preclinical models.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in oncology and neuropharmacology research programs.
• Signal Pathway Analysis: Employed to elucidate the p53 signaling pathway and its interactions with other cellular mechanisms.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes studying cell biology and apoptosis.

Basic Information

Item	Detail
Product Name	Cyclic-Pifithrin-Alpha
CAS No.	60477-34-1
Molecular Formula	C₁₃H₁₀N₂O₂S
Molecular Weight	258.30 g/mol
Synonyms	Cyclic Pifithrin-α; Pifithrin-α cyclic; PFT-α cyclic; 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone; p53 Inhibitor, Cyclic; Apoptosis Inhibitor, p53-dependent
EINECS	Contact for details

Quality Control

Our Cyclic-Pifithrin-Alpha is manufactured under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR, and mass spectrometry for structural confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.