Description

4-(Dimethyl-13C 2-Amino)Antipyrine is a stable isotope-labeled analog of the pharmaceutical intermediate 4-aminoantipyrine, where the two methyl groups are enriched with carbon-13. This compound is essential for advanced analytical research, providing a critical internal standard for precise quantification and metabolic pathway elucidation in mass spectrometry. It is primarily utilized by research institutions, pharmaceutical developers, and contract research organizations (CROs) engaged in pharmacokinetic studies, drug metabolism research, and the development of bioanalytical methods.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the accurate quantification of antipyrine and related metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of new chemical entities, leveraging the carbon-13 label for clear spectral differentiation.
• Biomedical Research: Facilitates precise metabolic pathway analysis in in vitro and in vivo studies, helping researchers understand enzyme activity and metabolic fate.
• Pharmaceutical Development: Employed in the development and validation of robust, GLP-compliant bioanalytical methods for preclinical and clinical trials.
• Stable Isotope Labeling: Acts as a building block for synthesizing more complex carbon-13 labeled compounds for specialized research applications.

Basic Information

Product Name	4-(Dimethyl-13C 2-Amino)Antipyrine
CAS No.	60433-90-1
Molecular Formula	C1113C2H15N3O
Molecular Weight	~207.24 g/mol (for 13C2 labeled form)
Synonyms	4-Aminoantipyrine-13C2 (dimethyl); 1,5-Dimethyl-2-phenyl-4-((dimethyl-13C2)amino)-3-pyrazolin-3-one; 4-(Dimethylamino-13C2)antipyrine; 4-Aminophenazone-13C2; 13C2-4-Aminoantipyrine; 4-AA-13C2; [13C2]-4-Aminoantipyrine
EINECS	Contact for details

Quality Control

Every batch of our 4-(Dimethyl-13C 2-Amino)Antipyrine is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing via NMR, HPLC, and mass spectrometry to confirm identity, potency, and isotopic enrichment. A detailed Certificate of Analysis (COA), including batch-specific data on purity, isotopic abundance, and residual solvents, is provided with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Isotopic Purity (by MS)	≥ 99% 13C2
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.