Description

6-Iodoamiloride Hydrochloride Dihydrate is a high-purity, iodinated derivative of the classic sodium channel blocker amiloride, widely utilized as a potent and selective pharmacological research tool. This compound is critical for investigating epithelial sodium channel (ENaC) function and related physiological pathways in academic and pharmaceutical research settings. It serves as an essential biochemical for researchers in cardiovascular, renal, and respiratory physiology, as well as in drug discovery programs targeting ion channel modulation.

Application

• Biochemical Research: Primary tool for the study and inhibition of epithelial sodium channels (ENaC) in cellular and tissue models.
• Pharmacology & Drug Discovery: Used as a reference standard and lead compound in the development of novel diuretics and antihypertensive agents.
• Academic Research: Fundamental for investigating ion transport mechanisms in renal physiology, lung fluid balance, and taste transduction.
• Proteomics & Molecular Biology: Employed in studies to understand protein-protein interactions and signaling pathways involving ENaC.
• Diagnostic Development: Potential use in the development of assays for screening compounds that modulate sodium channel activity.

Basic Information

Product Name	6-Iodoamiloride Hydrochloride Dihydrate
CAS No.	60398-23-4
Molecular Formula	C6H8ClIN6O • HCl • 2H2O
Molecular Weight	455.98 g/mol (anhydrous basis)
Synonyms	6-Iodoamiloride HCl Dihydrate; 3,5-Diamino-6-chloro-N-(diaminomethylene)-2-iodopyrazinecarboxamide Hydrochloride Dihydrate; N-Amidino-3,5-diamino-6-chloro-2-iodopyrazinecarboxamide Hydrochloride Dihydrate; 2-Iodoamiloride Hydrochloride Dihydrate; Benzamil Analog I; ENaC Blocker (Iodinated)
EINECS	Contact for details

Quality Control

Our 6-Iodoamiloride Hydrochloride Dihydrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) documenting identity, purity, and physicochemical properties is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to pale brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	7.0 - 9.0 %
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.