Description

Benzo(A)Pyrenyl-1-Glucuronide is a crucial glucuronide conjugate metabolite of Benzo[a]pyrene, a well-studied polycyclic aromatic hydrocarbon (PAH). This compound is essential for researchers and laboratories conducting advanced toxicological and metabolic studies, particularly in the fields of environmental health and cancer research. It serves as a vital analytical standard and reference material for scientists in pharmaceutical development, environmental monitoring, and regulatory toxicology who require high-purity metabolites for accurate quantification and mechanistic investigations.

Application

• Analytical Reference Standard: Primary use as a certified reference material (CRM) for the precise quantification of Benzo[a]pyrene metabolites in complex biological matrices via LC-MS/MS or HPLC.
• Toxicology & Metabolic Pathway Studies: Critical for investigating the Phase II detoxification (glucuronidation) pathways of PAHs, enabling research into bioactivation, detoxification mechanisms, and individual metabolic variability.
• Biomarker Development & Validation: Used in the development and validation of analytical methods to measure specific glucuronide conjugates as biomarkers of exposure to Benzo[a]pyrene in human biomonitoring studies.
• Environmental & Occupational Health Research: Supports studies assessing human exposure to combustion-derived pollutants, aiding in risk assessment for populations in industrial or high-pollution areas.
• Drug Metabolism Research (DMPK): Serves as a model compound for studying glucuronidation kinetics and enzyme (UGT) specificity in preclinical drug metabolism and pharmacokinetics (DMPK) research.
• Quality Control in Diagnostic Labs: Employed as an internal standard or calibrator in commercial diagnostic and analytical testing kits designed to measure PAH exposure.

Basic Information

Product Name	Benzo(A)Pyrenyl-1-Glucuronide
CAS No.	60262-82-0
Molecular Formula	C26H24O7
Molecular Weight	448.47 g/mol
Synonyms	1-Hydroxybenzo[a]pyrene 1-O-β-D-glucuronide; Benzo[a]pyren-1-yl-β-D-glucopyranosiduronic acid; 1-OH-BaP-1-O-glucuronide; BP-1-G; 1-Hydroxybenzo(a)pyrene glucuronide; Benzo[a]pyrene-1-glucuronide; 1-HBP-Gluc; BaP-1-Gluc
EINECS	Contact for details

Quality Control

Our Benzo(A)Pyrenyl-1-Glucuronide is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive analytical and research applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profile is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation. The container should be stored in a cool, dry, and well-ventilated area dedicated for research chemicals.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.