Description

3-Methylflavone-8-Carboxylic Acid Acyl--D-Glucuronide is a high-purity, conjugated metabolite reference standard critical for advanced analytical and research applications. This compound is essential for scientists and quality control professionals requiring definitive benchmarks for method development, validation, and metabolite identification studies. It is primarily utilized in pharmaceutical R&D, clinical research, and analytical laboratories focused on drug metabolism and pharmacokinetics (DMPK).

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantification and identification of drug metabolites in complex biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in in vitro and in vivo studies to elucidate metabolic pathways and assess the pharmacokinetic profile of parent flavonoid or drug compounds.
• Bioanalytical Method Development: Critical for developing and validating sensitive HPLC, LC-MS, and LC-MS/MS methods for accurate metabolite detection.
• Clinical Research & Toxicology: Employed as a calibrant in assays to monitor metabolite levels in clinical trials or toxicological evaluations.
• Impurity Profiling: Acts as a known impurity or degradation product standard for ensuring the purity and stability of active pharmaceutical ingredients (APIs).
• Academic & Contract Research: Supports fundamental research in medicinal chemistry, biochemistry, and pharmacology within universities and CROs.

Basic Information

Product Name	3-Methylflavone-8-Carboxylic Acid Acyl--D-Glucuronide
CAS No.	60218-13-5
Molecular Formula	C26H26O11
Molecular Weight	514.48 g/mol
Synonyms	3-Methylflavone-8-carboxylic acid β-D-glucuronide; 8-Carboxy-3-methylflavone glucuronide; 3-Methylflavone-8-carboxylate glucuronide; Acyl glucuronide of 3-methylflavone-8-carboxylic acid; Flavonoid metabolite standard; D-Glucopyranuronic acid, 1-[[8-(3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-5-yl)carbonyl]oxy]-, (1S)-; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 3-Methylflavone-8-Carboxylic Acid Acyl--D-Glucuronide is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced techniques like NMR, HPLC, and LC-MS. Our quality commitment ensures the material meets the stringent requirements for use as a high-grade reference standard in regulated and research environments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Under these conditions, the product is stable for extended periods. Allow the container to reach room temperature in a dry environment before opening to minimize condensation and potential moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.