Description

2,4-Difluoro-5-Nitropyridine CAS NO 60186-15-4 is a versatile fluorinated and nitrated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both electron-withdrawing fluorine and nitro groups, makes it a valuable precursor for creating complex heterocyclic compounds and active pharmaceutical ingredients (APIs). This high-purity intermediate is essential for research and development chemists, process engineers, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific functionalities into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in the synthesis of fluorinated heterocycles with potential biological activity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro and nitro groups can enhance metabolic stability and efficacy.
• Material Science Research: Serves as a precursor for functionalized ligands, organic electronic materials, and liquid crystals due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: An excellent substrate for metal-catalyzed reactions (e.g., Suzuki, Stille) to create complex, multi-substituted pyridine scaffolds.
• Nucleophilic Aromatic Substitution: The fluorine atoms at the 2- and 4- positions are highly reactive sites for substitution with various nucleophiles, enabling diverse chemical modifications.
• Chemical Research & Development: A valuable tool for academic and industrial R&D labs exploring new synthetic methodologies and fluorination chemistry.

Basic Information

Product Name	2,4-Difluoro-5-Nitropyridine
CAS No.	60186-15-4
Molecular Formula	C5H2F2N2O2
Molecular Weight	160.08 g/mol
Synonyms	5-Nitro-2,4-difluoropyridine; 2,4-Difluoro-5-nitropyridine; Pyridine, 2,4-difluoro-5-nitro-; 2,4-Difluoropyridine-5-nitro; 5-Nitro-2,4-difluoropyridin; 2,4-Difluoro-5-nitro-pyridine
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-5-Nitropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our commitment to consistent quality and traceability supports your development and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.