Description

4-Difluoro-3-Nitropyridine is a high-value, multi-functional heterocyclic building block characterized by its distinct fluorine and nitro substituents. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, where its reactive sites enable precise chemical modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for designing novel liquid crystals, organic semiconductors, and polymers with tailored electronic properties.
• Cross-Coupling Reactions: The nitro and fluorine groups make it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to build complex biaryl systems.
• Nucleophilic Aromatic Substitution: The fluorine atoms are susceptible to displacement, allowing for the introduction of various amines, alkoxides, and thiols to create diverse pyridine libraries.
• Chemical Biology & Probe Development: Utilized in creating fluorescent tags, enzyme inhibitors, and other molecular probes for biochemical research and diagnostic applications.

Basic Information

Product Name	4-Difluoro-3-Nitropyridine
CAS No.	60186-14-3
Molecular Formula	C5H2F2N2O2
Molecular Weight	160.08 g/mol
Synonyms	3-Nitro-4,5-difluoropyridine; 4,5-Difluoro-3-nitropyridine; 3-Nitro-4,5-difluoropyridine; Pyridine, 4,5-difluoro-3-nitro-; 4,5-Difluoro-3-nitro-pyridine
EINECS	Contact for details

Quality Control

Our 4-Difluoro-3-Nitropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.