Description

Phenprocoumon Glucuronide is a key metabolite and reference standard of the anticoagulant drug phenprocoumon. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily used by analytical laboratories, pharmaceutical manufacturers, and academic research institutions engaged in cardiovascular drug development and clinical testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of phenprocoumon and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, clearance mechanisms, and bioavailability of the parent anticoagulant drug.
• Bioanalytical Method Development: Used to validate HPLC, LC-MS, and LC-MS/MS methods for accurate detection and quantification in plasma, serum, and urine samples.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Supports studies aiming to correlate drug metabolite levels with therapeutic efficacy and safety profiles in patients.
• Impurity Profiling: Employed in the quality control of active pharmaceutical ingredients (APIs) to identify and quantify glucuronide-related impurities.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring detailed characterization of drug metabolites.

Basic Information

Product Name	Phenprocoumon Glucuronide
CAS No.	60002-13-3
Molecular Formula	C25H24O10
Molecular Weight	484.45 g/mol
Synonyms	Phenprocoumon β-D-Glucuronide; 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one Glucuronide; Phenprocoumon Glucuronide Metabolite; Marcoumar Glucuronide; 3-(1-Phenylpropyl)-4-hydroxycoumarin Glucuronide; Phenprocoumon 4-O-β-D-Glucuronide; Phenprocoumon Glucuronide (major metabolite)
EINECS	Contact for details

Quality Control

Our Phenprocoumon Glucuronide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) detailing all specifications, ensuring the material meets the high standards required for pharmaceutical research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric humidity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.