Description

A,A-Difluoro-A-Chloro-4-Chlorotoluol is a specialized fluorinated and chlorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role in introducing difluoromethyl and chloro substituents into molecular frameworks, enabling the fine-tuning of physical, chemical, and biological properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those requiring difluoromethyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the introduction of fluorine and chlorine atoms can improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and advanced organic electronic materials with specific dielectric properties.
• Fluorination Chemistry: A valuable reagent in methodological studies for introducing gem-difluoro groups into complex organic molecules under controlled conditions.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for client-specific projects requiring this unique halogenated toluene derivative.

Basic Information

Product Name	A,A-Difluoro-A-Chloro-4-Chlorotoluol
CAS No.	6987-14-0
Molecular Formula	C7H4Cl2F2
Molecular Weight	197.01 g/mol
Synonyms	α,α-Difluoro-α-chloro-4-chlorotoluene; 4-Chlorobenzylidene Chlorodifluoride; (Dichlorofluoromethyl)-4-chlorobenzene; 1-Chloro-4-[(dichlorofluoromethyl)methyl]benzene; Benzene, 1-chloro-4-[(dichlorofluoromethyl)methyl]-; 4-Chloro-α,α-difluoro-α-chlorotoluene; PCBTF (related compound, verify context); Difluorochloromethyl-4-chlorobenzene
EINECS	Contact for details

Quality Control

Our A,A-Difluoro-A-Chloro-4-Chlorotoluol is produced and handled under a strict quality management system. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly closed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.