Description

Nonactin CAS NO 6833-84-7 is a potent, naturally occurring ionophore antibiotic belonging to the macrotetrolide family. Its primary value lies in its high selectivity for potassium ions (K⁺), making it an essential biochemical tool for modulating membrane potential and ion transport in research. This compound is critically needed by researchers in biochemistry, pharmacology, and physiology for studying ion channels, mitochondrial function, and as a model for transmembrane carrier mechanisms.

Application

• Biochemical Research: As a selective potassium ionophore to study ion transport across lipid bilayers and artificial membranes.
• Mitochondrial Studies: Used to investigate mitochondrial function by uncoupling oxidative phosphorylation via K⁺ transport.
• Membrane Potential Modulation: A key tool for manipulating and measuring membrane potential in cells and vesicles.
• Antimicrobial Research: Serves as a reference standard in studies of antibiotic mechanisms and ionophore activity.
• Sensor Development: Employed in the fabrication of ion-selective electrodes (ISEs) for potassium detection.
• Model Compound: Used in structural and computational studies of ion binding and carrier-mediated transport.

Basic Information

Product Name	Nonactin
CAS No.	6833-84-7
Molecular Formula	C₄₀H₆₄O₁₂
Molecular Weight	736.93 g/mol
Synonyms	Nonactin; Macrotetrolide Antibiotic; NSC 77113; Ionophore Nonactin; Antibiotic X 464; Antimycin A; (3S,6R,9S,12R,15S,18R,21S,24R)-3,6,9,12,15,18,21,24-Octamethyl-1,4,7,10,13,16,19,22-octaoxacyclotetracosan-2,5,8,11,14,17,20,23-octone
EINECS	229-904-7

Quality Control

Our Nonactin is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.